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What is Andarine (S-4)?
Andarine (S-4) is categorized as a SARM as well as a research chemical. S-4 was designed to treat several severe medical conditions, such as, muscle wasting, osteoporosis and benign prostatic hyptertrophy, using the non-steroidal androgen antagonist bicalutamide as a lead compound.
S-4 is an orally partial agonist for androgen receptors. Carrying this quality allows S4 to maintain and add lean body mass. When being compared to testosterone and other forms of steroids, the advantages of SARMS like S4, is they do not have androgenic activity in non-skeletal muscles.
S4 is often thought of as the strongest SARM, in terms of the many capabilities it has. It is a lean body mass builder, as well as strength and vascularity enhancer.
How does it work?
SARMS themselves bind to the AR (androgen receptor) and demonstrate osteo (bone) and myo (muscular anabolic activity. When something binds and activates the AR, it alters the expression of genes and increases protein synthesis, which in turn builds muscle.
SARMS cause muscle growth in the same method as steroids, the difference being that SARMS do not enhance the growth of ones prostate and other sexual organs. SARMS do not cause the many problems that anabolics can cause. SARMS do not have toxicity, in some circumstances only cause minimal suppression, allowing for a rapid recovery, as opposed to steroids that can cause long term problems from the high rates of suppression and provide a sense of well being each day that many steroids cannot cause.
S4 binds to the AR in muscle and bone at a third of the affinity as testosterone.
Evidence of S-4 Abilities?
Several studies have been conducted on S4. Here are some of the results found:
S4 dosed at 3 mg/kg/day had the ability to restore strength and skeletal muscle in castrated rats which proves it's ability for the treatment of muscle wasting and male HRT.
In a 120 day study comparing S4 to DHT (dihydrostesterone) treatment in overiectomized rats, showed S4 had the ability to maintain bone strength and mass and that S4 exhibited a much higher efficacy rate than DHT as well.
As noted earlier, S4 showed the ability to improve skeletal muscle strength but also to increase lean body mass, reduce body fat and prevent bone loss.
Strength gains and Lean mass gains
Andarine (S-4) is well known for the increases in strength that it provides. S4 provides huge amounts of strength, stamina and aides in rapid recovery. There is no estrogen conversion, no water retention or bloat and no toxicity. S4 is anabolic in nature so strength gains are obtained rapidly and lean mass is the primary attainment from use.
S-4 has a very short half life, spanning 4-6 hours, thus requiring multiple dosing. It is optimal to take one dose in the morning and another 4-6 hours later. Due to the short half life, many have found it to be optimal to take one dose 30 minutes prior to a workout, resulting with increased performance in the gym.
S-4 side effects
Andarine (S-4) does not carry many side effects but there is often one well known side effect commonly associated with use. It sounds far more than it actually is so a deep understanding of it is required. Many researchers often report night vision problems when using S4. These are not permanent and only present with S4 use. In short, a metabolite of S4 binds to the receptor in the eye, causing a yellow tint to appear when switching from dark to lighted areas, especially prevalent in the evenings. It is impossible to gauge if/when/how it binds and how bad the effect can be. Some barely experience it at all while others can find it more difficult to manage.
Although these side effects are temporary, if they are still a concern, as suggested earlier, a 5 on 2 off protocol where S-4 is used for 5 days followed by a 2 day break (then this cycle is repeated) would be the suggested research dosing method.
S4 does not aromatize, nor do any other SARMS. S4 has never shown any sort of estrogen elevation. Since it has slight androgenic activity, it gives the opposite effect and actually reduces any bloating present. The hardening effects S4 provides only confirms this.
Some users have shown very slight suppression when using S4. A short, mini post cycle therapy regiment is required with use, but the recovery time is only 2-3 weeks after completion.
Advantages Of S4 when compared to Steroids/Prohormones
- S4 is non toxic and has no negative effect on the liver, blood pressure or any other internal organs.
- There is not a full post cycle therapy nor recovery period required (generally only 2-3 weeks)
- Researchers will have a far greater sense of well being while on S4
- There is not a significant requirement for time off in between cycles.
- S4 provides steroid like results without the steroid like side effects